Exploration enrichment pathways with differentially expressed (DE) genes between old versus young
Team Le Grand
02 mai,2022
Pathway explored : REACTOME RNA POLYMERASE II TRANSCRIPTION
This pathway contain 1206 genes.
In these 1206 genes for each day and cell type, they are not all expressed and they are not all differentially expressed between old versus young.
Inside these differents genes, there are (cf table below) number of genes DE significant with a major participation in the enrichment (leadingEdge cal by fgsea filter by padj<0.05).
| D2_MuSCs | D4_MuSCs |
|---|---|
| 96 | 78 |
| Igfbp3 E2f7 Met Cdk6 Sgk1 Rbbp8 H2az1 Atad2 Suz12 Npm1 Dek Gata2 Dll1 Lbr Zik1 Tead2 Rbl1 Atm Topbp1 Hspd1 Srsf1 Cbx2 Supt16 Blm Snrpg Aurka Rrm2 Cdk4 Brip1 Rad51 Cstf2 E2f8 Cdk1 Sumo1 Mybl2 Prmt5 Cnot6 Srsf7 Bard1 Tfdp1 Cdk8 Psme3 Magohb Nudt21 Chek1 Rbbp4 Srsf2 Snrpe Alyref Cbx5 Myb Taf2 Kmt5a Exo1 Zfp706 Kras Ssrp1 Eed Pitx2 Cbfb Aurkb Casp2 Ctsl Cdk2 Slbp Gtf2h1 Trim28 Parp1 Tpx2 Psmd5 Rps27a Tgfa Rad17 Hus1 Ints2 Cnot9 Prmt1 Ezh2 Srsf11 Ndufa4 Rpa3 Rpa1 Pbrm1 Skp2 Magoh Gatad2a Dpy30 Prkaa1 Psma3 Cnot6l Rnps1 Srsf3 Ints7 Psma6 Psmd1 U2af2 | Thbs1 Hspd1 Rrm2 Npm1 Cdkn1a Dek H2az1 E2f8 Rpa1 Calm1 Nr4a2 Topbp1 Ctsl Cbx5 Lgals3 Atad2 H2ax Ywhaz Prmt1 Psmd14 Cox6a1 Prdx1 Srsf1 Cited2 Ywhae Cdk1 Parp1 Ssrp1 Rbl1 Plk2 Srsf2 Psmd1 Tfdp1 Txn1 Mybl2 Dyrk2 Psmb6 Tpx2 Gpi1 Mdm2 Kmt5a G6pdx Lbr Upf3b Klf4 Psmd12 Psmd11 E2f4 Polr2a Cdk6 Aurkb Suz12 Camk2d Tead4 Slbp Cnot9 Cox7b Nr4a1 Psmb3 Eed Cox5a Dll1 Vegfa Sgk1 Psmd2 Steap3 Cox5b Tbl1xr1 Psma1 Psma7 Psmd5 Cpsf2 Srsf3 Pparg Psmd7 Psma5 Rb1 Gtf2a1 |
Dynamic through conditions (day and type cell): D2_MuSCs_Down.D4_MuSCs_Up
Heatmap of the top 40 genes DE between old versus young
Scale borned by min and max meancountnormalised and log2foldchange of all dataset
Scale free
Expression of genes DE in this pathway through days and type cells for young versus old
Scale borned by min and max meancountnormalised and log2foldchange of all dataset
Scale free
